Solid-phase extraction and elution on diamond (SPEED): a fast and general platform for proteome analysis with mass spectrometry.

@article{Chen2006SolidphaseEA,
  title={Solid-phase extraction and elution on diamond (SPEED): a fast and general platform for proteome analysis with mass spectrometry.},
  author={Wei-Hao Chen and S Lee and Sahadevan Sabu and Huei-Chun Fang and Shu-Chien Chung and Chau-Chung Han and Huan-Cheng Chang},
  journal={Analytical chemistry},
  year={2006},
  volume={78 12},
  pages={4228-34}
}
This paper presents a new solid-phase extraction and elution platform based on surface-functionalized diamond nanocrystallites. Compared with conventional methods, the platform facilitates purification and concentration of intact proteins and their enzymatic digests for ensuing sodium dodecyl sulfate-polyacrylamide gel electrophoresis or matrix-assisted laser desorption/ionization mass spectrometry analysis without prior removal of the adsorbent. One-pot work flow involving reduction of… CONTINUE READING

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