Solid-phase extraction/MALDI-MS: extended ion-pairing surfaces for the on-target cleanup of protein samples.

The surface of a matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) target can be covalently modified so that it behaves like a medium for solid-phase extraction (SPE). These modified targets are capable of binding molecules of interest, but not contaminants, from sample solutions placed on them. This allows the analyte to be cleaned… CONTINUE READING