Solid phase combinatorial library of phosphinic peptides for discovery of matrix metalloproteinase inhibitors.

@article{Buchardt2000SolidPC,
  title={Solid phase combinatorial library of phosphinic peptides for discovery of matrix metalloproteinase inhibitors.},
  author={Jens Buchardt and Christine Bruun Schi\odt and Christian Krog-Jensen and J. M. Delaiss{\'e} and Niels T{\ae}kker Foged and Morten Meldal},
  journal={Journal of combinatorial chemistry},
  year={2000},
  volume={2 6},
  pages={624-38}
}
A solid phase combinatorial library of 165,000 phosphinic peptide inhibitors was prepared and screened for activity against MMP-12. The inhibitors of the library had the structure XXX-Gpsi(PO2H-CH2)L-XXX, in which X is an arbitrary amino acid and Gpsi(PO2H-CH2)L is a Gly-Leu phosphinic dipeptide analogue. The library was constructed as a one-bead-two-compounds library so that every bead contained a common quenched fluorogenic substrate and a different putative inhibitor. In addition, the… CONTINUE READING

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