Solid phase assay of urine cystine supersaturation in the presence of cystine binding drugs.

@article{Coe2001SolidPA,
  title={Solid phase assay of urine cystine supersaturation in the presence of cystine binding drugs.},
  author={Fredric L. Coe and Curtis J Clark and Joan H. Parks and John R. Asplin},
  journal={The Journal of urology},
  year={2001},
  volume={166 2},
  pages={688-93}
}
PURPOSE We report a new kind of assay system for urine cystine supersaturation that is accurate in the presence of cystine binding thiol drugs. We measured the molar ratio of cystine dissolved per mole of drug. MATERIALS AND METHODS Measured amounts of cystine crystals were incubated in buffer or urine for 48 hours with stirring. The solid phase remaining was pelleted by centrifugation, extracted into a high pH buffer and measured. D-penicillamine, tiopronin and captopril were added to… CONTINUE READING

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