Solid nanocrystalline dispersions of ziprasidone with enhanced bioavailability in the fasted state.

@article{Thombre2012SolidND,
  title={Solid nanocrystalline dispersions of ziprasidone with enhanced bioavailability in the fasted state.},
  author={Avinash G. Thombre and Warren B. Caldwell and Dwayne T. Friesen and Scott B. McCray and Steven C. Sutton},
  journal={Molecular pharmaceutics},
  year={2012},
  volume={9 12},
  pages={3526-34}
}
Reducing the absorption difference between fed and fasted states is an important goal in the development of pharmaceutical dosage forms. The goal of this work was to develop and characterize a solid nanocrystalline dispersion (SNCD) to improve the oral absorption of ziprasidone in the fasted state, thereby reducing the food effect observed for the… CONTINUE READING