Solid lipid nanoparticles of temozolomide: potential reduction of cardial and nephric toxicity.

@article{Huang2008SolidLN,
  title={Solid lipid nanoparticles of temozolomide: potential reduction of cardial and nephric toxicity.},
  author={Guihua Huang and Na Zhang and Xiuli Bi and Mingjin Dou},
  journal={International journal of pharmaceutics},
  year={2008},
  volume={355 1-2},
  pages={314-20}
}
The aim of this study was to prepare temozolomide solid lipid nanoparticles (TMZ-SLNs), to evaluate its physiochemical characteristics, and to investigate the specific drug targeting of intravenous (i.v.) injected solid lipid nanoparticles of temozolomide. TMZ-SLNs was prepared by an emulsification and low-temperature solidification method. In vitro drug release was conducted in phosphate-buffered saline (pH 6.8) at 37 degrees C. The concentrations of the temozolomide in selected organs were… CONTINUE READING
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Solid lipid nanoparticles ( SLN ) as potential carrier for human use : interaction with human granulocytes

  • S. Maassen, C. Schwarz, W. Mehnert
  • J . Control . Release
  • 1997

Controlled drug delivery with nanoparticles : current possibilities and future trends

  • P. ouvreur, C. Dubernet, F. Puisieux
  • Eur . J . Pharm . Biopharm .
  • 1995

Mechanisms regulating body distribution of nanospheres conditioned with pluronic and tetronic block copolymers

  • A. ur Muhlen, C. Schwarz, W. Mehnert
  • Adv . Drug Deliv . Rev .
  • 1995

Nanocapsules with a reduced liver uptake : targeting of phthalocyanines to EMT6 mouse mammary tumour in vivo

  • K. anjunath, V. Venkateswarlu
  • Eur . J . Pharm . Biopharm .
  • 1995

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