Solid lipid nanoparticles modified with stearic acid–octaarginine for oral administration of insulin

@inproceedings{Zhang2012SolidLN,
  title={Solid lipid nanoparticles modified with stearic acid–octaarginine for oral administration of insulin},
  author={Zhen-hai Zhang and Yin-long Zhang and Jianping Zhou and Hui-Xia Lv},
  booktitle={International journal of nanomedicine},
  year={2012}
}
The aim of this study was to design and characterize solid lipid nanoparticles (SLNs) modified with stearic acid-octaarginine (SA-R₈) as carriers for oral administration of insulin (SA-R₈-Ins-SLNs). The SLNs were prepared by spontaneous emulsion solvent diffusion methods. The mean particle size, zeta potential, drug loading, and encapsulation efficiency of the SA-R₈-Ins-SLNs were 162 nm, 29.87 mV, 3.19%, and 76.54%, respectively. The zeta potential of the SLNs changed dramatically, from -32.13… CONTINUE READING

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