Solid lipid nanoparticles for pulmonary delivery of insulin.

@article{Liu2008SolidLN,
  title={Solid lipid nanoparticles for pulmonary delivery of insulin.},
  author={Jie Liu and Tao Gong and Hua-lin Fu and Changguang Wang and Xiuli Wang and Qian Chen and Qin Zhang and Qin He and Zhirong Zhang},
  journal={International journal of pharmaceutics},
  year={2008},
  volume={356 1-2},
  pages={
          333-44
        }
}
Growing attention has been given to the potential of pulmonary route as an alternative for non-invasive systemic delivery of therapeutic agents. In this study, novel nebulizer-compatible solid lipid nanoparticles (SLNs) for pulmonary drug delivery of insulin were developed by reverse micelle-double emulsion method. The influences of the amount of sodium cholate (SC) and soybean phosphatidylcholine (SPC) on the deposition properties of the nanoparticles were investigated. Under optimal… CONTINUE READING
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