Solid lipid nanoparticles for ocular drug delivery

@article{Seyfoddin2010SolidLN,
  title={Solid lipid nanoparticles for ocular drug delivery},
  author={Ali Seyfoddin and John P. Shaw and Raida S Al-Kassas},
  journal={Drug Delivery},
  year={2010},
  volume={17},
  pages={467 - 489}
}
Ocular drug delivery remains challenging because of the complex nature and structure of the eye. Conventional systems, such as eye drops and ointments, are inefficient, whereas systemic administration requires high doses resulting in significant toxicity. There is a need to develop novel drug delivery carriers capable of increasing ocular bioavailability and decreasing both local and systemic cytotoxicity. Nanotechnology is expected to revolutionize ocular drug delivery. Many nano-structured… 

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References

SHOWING 1-10 OF 120 REFERENCES

Nanocarriers in ocular drug delivery: an update review.

This review presents an overview of the various aspects of the ocular drug delivery, with special emphasis on nanocarrier based strategies, including structure of eye, its barriers, delivery routes and the challenges/limitations associated with development of novelnanocarriers.

Polymeric nanoparticulate system: a potential approach for ocular drug delivery.

Microspheres and nanoparticles used in ocular delivery systems

Nanotechnology in ocular drug delivery.

Liposome ocular delivery systems

Colloidal carriers for ophthalmic drug delivery.

This review will discuss recent progress and specific development issues relating to colloidal drug delivery systems, such as liposomes, niosomes, nanoparticles, and microemulsions in ocular drug delivery, and the benefits of using colloidal carriers in intravitreal injections for posterior drug delivery.

Ophthalmic drug delivery systems—Recent advances

Nanomedicines for ocular NSAIDs: safety on drug delivery.

Vesicular systems in ocular drug delivery: an overview.

Incorporation of liquid lipid in lipid nanoparticles for ocular drug delivery enhancement

Results indicated that NLC was a biocompatible and potential nanocarrier for ocular drug delivery enhancement and could improve the ocular retention and penetration of ocular therapeutics.
...