Solid lipid nanoparticles as vehicles of drugs to the brain: current state of the art.

@article{Gastaldi2014SolidLN,
  title={Solid lipid nanoparticles as vehicles of drugs to the brain: current state of the art.},
  author={Lucia Gastaldi and Luigi Battaglia and Elena Peira and Daniela Chirio and Elisabetta Muntoni and Ilaria Solazzi and Marina Gallarate and Franco Dosio},
  journal={European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V},
  year={2014},
  volume={87 3},
  pages={433-44}
}
Central nervous system disorders are already prevalent and steadily increasing among populations worldwide. However, most of the pharmaceuticals present on world markets are ineffective in treating cerebral diseases, because they cannot effectively cross the blood brain barrier (BBB). Solid lipid nanoparticles (SLN) are nanospheres made from biocompatible solid lipids, with unique advantages among drug carriers: they can be used as vehicles to cross the BBB. This review examines the main… CONTINUE READING