Solid lipid extrudates as sustained-release matrices: the effect of surface structure on drug release properties.

@article{Reitz2008SolidLE,
  title={Solid lipid extrudates as sustained-release matrices: the effect of surface structure on drug release properties.},
  author={Claudia Reitz and Clare J Strachan and Peter Kleinebudde},
  journal={European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences},
  year={2008},
  volume={35 4},
  pages={335-43}
}
The study focused on the structural characterization of sustained-release lipid matrices prepared by solid lipid extrusion. Drug-containing lipid extrudates were locally analyzed in order to identify differences between the chemical and structural composition of surface and core elements. Independent of the lipid the dissolution from the outer extrudate surfaces was slower compared with dissolution from surfaces prepared by cutting the extrudate. The burst effect was higher for the cross… CONTINUE READING