Solid ionic matrixes for direct tissue analysis and MALDI imaging.

  title={Solid ionic matrixes for direct tissue analysis and MALDI imaging.},
  author={R{\'e}mi Lemaire and J C Tabet and Patrick Ducoroy and J B Hendra and Michel Salzet and Isabelle Fournier},
  journal={Analytical chemistry},
  volume={78 3},
Direct analysis of tissue by MALDI-MS allows the acquisition of its biomolecular profile while maintaining the integrity of the tissue, giving cellular localization, and avoiding tedious extraction and purification steps. However, direct tissue analysis generally leads to some extent to a lowered spectral quality due to variation in thickness, freezing tissue date, and nature of the tissue. We present here new technical developments for the direct tissue analysis of peptides with ionic liquid… CONTINUE READING


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