Solid formulations by a nanocrystal approach: critical process parameters regarding scale-ability of nanocrystals for tableting applications.

@article{Tuomela2015SolidFB,
  title={Solid formulations by a nanocrystal approach: critical process parameters regarding scale-ability of nanocrystals for tableting applications.},
  author={Annika Tuomela and Timo Laaksonen and Johanna Laru and Osmo Antikainen and Juha Kiesvaara and Jukka Ilkka and Olli Oksala and Seppo R{\"o}nkk{\"o} and K. J{\"a}rvinen and Jouni Hirvonen and L. Peltonen},
  journal={International journal of pharmaceutics},
  year={2015},
  volume={485 1-2},
  pages={77-86}
}
Nanocrystallization is among the foremost drug delivery platform approaches for the commercial development of poorly soluble drugs. There exists an urge to enable a universal shift of the production of the solid nanocrystal formulations from laboratory scale to industrially feasible scale. The success of any formulation development depends on its transferability to large scale manufacture. The objectives of the study were to increase the nanocrystallization batch size and to screen and optimize… CONTINUE READING