Solid dispersions of nimodipine and polyethylene glycol 2000: dissolution properties and physico-chemical characterisation.

@article{Urbanetz2005SolidDO,
  title={Solid dispersions of nimodipine and polyethylene glycol 2000: dissolution properties and physico-chemical characterisation.},
  author={Nora Anne Urbanetz and Bernhard Christian Lippold},
  journal={European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V},
  year={2005},
  volume={59 1},
  pages={107-18}
}
The incorporation of a drug in a carrier by melt embedding may either result in a solid solution or in a solid suspension of the active ingredient within the carrier material. As the dispersivity of the drug is of outstanding importance for its dissolution characteristics, parameters which are supposed to influence crystallinity and dispersivity, e.g. cooling rate during preparation and storage conditions like temperature and relative humidity are investigated. It is found that the absence of… CONTINUE READING

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