Solid-State NMR Characterization of Autofluorescent Fibrils Formed by the Elastin-Derived Peptide GVGVAGVG

  title={Solid-State NMR Characterization of Autofluorescent Fibrils Formed by the Elastin-Derived Peptide GVGVAGVG},
  author={Simon Sharpe and Karen D Simonetti and Jason Yau and Patrick M. Walsh},
The characterization of the molecular structure and physical properties of self-assembling peptides is an important aspect of optimizing their utility as scaffolds for biomaterials and other applications. Here we report the formation of autofluorescent fibrils by an octapeptide (GVGVAGVG) derived via a single amino acid substitution in one of the hydrophobic repeat elements of human elastin. This is the shortest and most well-defined peptide so far reported to exhibit intrinsic fluorescence in… CONTINUE READING


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Angew. Chem., Int. Ed

  • W S Childers, A K Mehta, R Ni, J V Taylor, D G Lynn
  • Angew. Chem., Int. Ed
  • 2010

J. H. Pept. Sci

  • J P Jung, J Z Gasiorowski, Collier
  • J. H. Pept. Sci
  • 2010

Pept. Sci

  • S R Macewan, A Chilkoti
  • Pept. Sci
  • 2010

Curr. Opin. Chem. Biol

  • W S Childers, R Ni, A K Mehta, D G Lynn
  • Curr. Opin. Chem. Biol
  • 2009


  • K Ohgo, W P Niemczura, T Muroi, A K Onizuka, K K Kumashiro
  • Macromolecules
  • 2009


  • P Walsh, K Simonetti, S Sharpe
  • Structure
  • 2009


  • H Nuhn, H Klok
  • Biomacromolecules
  • 2008

J. Am. Chem. Soc

  • J Madine, E Jack, P G Stockley, S E Radford, L C Serpell, D A Middleton
  • J. Am. Chem. Soc
  • 2008


  • C Wasmer, A Lange, H Van Melckebeke, A B Siemer, R Riek, B Meier
  • Science
  • 2008


  • J J Mcfarlane, H T Madsen, A O Riekel, C Eisenberg
  • Nature
  • 2007

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