Solid-State Characterization and Compatibility Studies of Penciclovir, Lysine Hydrochloride, and Pharmaceutical Excipients

  title={Solid-State Characterization and Compatibility Studies of Penciclovir, Lysine Hydrochloride, and Pharmaceutical Excipients},
  author={Rafaela Z C Meira and Isabela F B Biscaia and Camila Tita Nogueira and F{\'a}bio S. Murakami and Larissa Sakis Bernardi and Paulo R Oliveira},
The physical and chemical characterization of the solid-state properties of drugs and excipients is fundamental for planning new formulations and developing new strategies for the treatment of diseases. Techniques such as differential scanning calorimetry, thermogravimetry, X-ray powder diffraction, Fourier transform infrared spectroscopy, and scanning electron microscopy are among the most commonly used techniques for these purposes. Penciclovir and lysine are individually used to treat the… Expand
7 Citations
Physicochemical compatibility studies of triclosan and flurbiprofen with excipients of pharmaceutical formulation using binary, ternary, and multi-combination approach
The aim of the study was to evaluate the suitability of triclosan (TCS) and flurbiprofen (FLB) with poly-ε-caprolactone (PCL), chitosan (CS), and Kolliphor® P188 (KP) for possible application in theExpand
Stability and Compatibility Studies of Levothyroxine Sodium in Solid Binary Systems—Instrumental Screening
The corroboration of instrumental results led to the conclusion that LTSS is incompatible with lactose, mannitol and sorbitol, and these excipients should not be considered in the development of new generic solid formulations. Expand
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Cocrystals of Penciclovir with Hydroxybenzoic Acids: Synthesis, Crystal Structures, and Physicochemical Evaluation
Penciclovir, a potent and selective inhibitor of herpes viruses, cannot be formulated in oral preparations as it shows low oral bioavailability (5–10%) due to its poor solubility and/or poor permea...
Evaluation of drug repositioning by molecular docking of pharmaceutical resources available in the Brazilian healthcare system against SARS-CoV-2
The results point to a potential effectiveness of Penciclovir, Ribavirin, and Zanamivir, from a set of 48 potential candidates, showing high affinity with more than one viral protein, in the treatment of SARS-CoV-2. Expand
Current Antivirals and Novel Botanical Molecules Interfering With Herpes Simplex Virus Infection
Currently available anti-herpetic therapies, novel molecules being assessed in clinical trials and new botanical compounds reported in the last 20 years with antiviral activities against HSVs that might represent future treatments against these viruses are reviewed. Expand


Solid-state compatibility studies of a drug without melting point
In preliminary pre-formulation studies, the evaluation of solid-state interactions between an active pharmaceutical ingredient and different excipients is essential to guarantee the quality of theExpand
Compatibility of the antitumoral beta-lapachone with different solid dosage forms excipients.
Evaluating the compatibility of the beta-lapachone (betaLAP), an antitumoral drug in clinical phase, with pharmaceutical excipients of common use including diluents, binders, disintegrants, lubricants and solubilising agents confirmed the incompatibility of betaLAP with magnesium stearate and dicalcium phosphate dihydrate. Expand
Penciclovir solubility in Eudragit films: a comparison of X-ray, thermal, microscopic and release rate techniques.
The solubility of penciclovir (C(10)N(5)O(3)H(17)) in a novel film formulation designed for the treatment of cold sores was determined using X-ray, thermal, microscopic and release rate techniques.Expand
Compatibility studies of lapachol with pharmaceutical excipients for the development of topical formulations
Among naphthoquinones, lapachol and many heterocyclic derivatives have been investigated during the past years, mainly due to their antibacterial, antifungal and anticancer activities. Assessment ofExpand
Thermal analysis and compatibility studies of prednicarbate with excipients used in semi solid pharmaceutical form
Differential Scanning Calorimetry (DSC), thermogravimetry/derivative thermogravimetry (TG/DTG) and infrared spectroscopy (IR) techniques were used to investigate the compatibility betweenExpand
Performance comparison between crystalline and co-amorphous salts of indomethacin-lysine.
Overall, it has been shown that the co-amorphous form of a salt has a superior performance in comparison to a crystalline Salt of indomethacin with amino acid lysine. Expand
Drug-excipient compatibility studies in binary and ternary mixtures by physico-chemical techniques
This work is part of a systematic study undertaken to find and optimize a general method of detecting the drug-excipient interactions, with the aim of predicting rapidly and inexpensively the longExpand
Compatibility study of rivaroxaban and its pharmaceutical excipients
Rivaroxaban is an oral direct Factor Xa inhibitor to treat thrombus. The aim of this study is to investigate the drug–excipient compatibility between rivaroxaban tablet and pharmaceutical excipientsExpand
Formulation design of microemulsion for dermal delivery of penciclovir.
The conclusion was that the permeating ability of penciclovir was significantly increased from the microemulsion formulation compared with commercial cream. Expand
Synthesis, Characterization and Antiviral Properties of Pd(II) Complexes With Penciclovir
The synthesized and characterized new binary and ternary complexes of Pd(II) of formulae cis-(pen)2PdCl2 and cis,[(nucl) 2Pd( pen)2]Cl2, where nucl = guanosine, inosine, cytidine or penciclovir, and all the prepared complexes were markedly active against HSV-1 andHSV-2 strains. Expand