Solar ultraviolet irradiation reduces collagen in photoaged human skin by blocking transforming growth factor-beta type II receptor/Smad signaling.

@article{Quan2004SolarUI,
  title={Solar ultraviolet irradiation reduces collagen in photoaged human skin by blocking transforming growth factor-beta type II receptor/Smad signaling.},
  author={Taihao Quan and Tianyuan He and Sewon Kang and John J. Voorhees and Gary J. Fisher},
  journal={The American journal of pathology},
  year={2004},
  volume={165 3},
  pages={741-51}
}
Ultraviolet (UV) irradiation from the sun reduces production of type I procollagen (COLI), the major structural protein in human skin. This reduction is a key feature of the pathophysiology of premature skin aging (photoaging). Photoaging is the most common form of skin damage and is associated with skin carcinoma. TGF-beta/Smad pathway is the major regulator of type I procollagen synthesis in human skin. We have previously reported that UV irradiation impairs transforming growth factor-beta… CONTINUE READING
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