Power in the phenotypic extremes: a simulation study of power in discovery and replication of rare variants.
- Lin T Guey, Jasmina Kravic, +14 authors Benjamin F Voight
- Genetic epidemiology
- 2011
Highly Influenced
4 Excerpts
Software for generating liability distributions for pedigrees conditional on their observed disease states and covariates.
- Published 2010 in Genetic epidemiology
Abstract
For many multifactorial diseases, aetiology is poorly understood. A major research aim is the identification of disease predictors (environmental, biological, and genetic markers). In order to achieve this, a two-stage approach is proposed. The initial or synthesis stage combines observed pedigree data with previous genetic epidemiological research findings… (More)