Software applications toward quantitative metabolic flux analysis and modeling

@article{Dandekar2014SoftwareAT,
  title={Software applications toward quantitative metabolic flux analysis and modeling},
  author={Thomas Dandekar and Astrid Fieselmann and Saman Majeed and Zeeshan Ahmed},
  journal={Briefings in bioinformatics},
  year={2014},
  volume={15 1},
  pages={91-107}
}
Metabolites and their pathways are central for adaptation and survival. Metabolic modeling elucidates in silico all the possible flux pathways (flux balance analysis, FBA) and predicts the actual fluxes under a given situation, further refinement of these models is possible by including experimental isotopologue data. In this review, we initially introduce the key theoretical concepts and different analysis steps in the modeling process before comparing flux calculation and metabolite analysis… CONTINUE READING
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