Softening Substrates Promote Chondrocytes Phenotype via RhoA/ROCK Pathway.

@article{Zhang2016SofteningSP,
  title={Softening Substrates Promote Chondrocytes Phenotype via RhoA/ROCK Pathway.},
  author={Tao Zhang and Tao Gong and Jing Xie and Shi yu Lin and Yao Liu and Tengfei Zhou and Yunfeng Lin},
  journal={ACS applied materials & interfaces},
  year={2016},
  volume={8 35},
  pages={
          22884-91
        }
}
Due to its evascular, aneural, and alymphatic conditions, articular cartilage shows extremely poor regenerative ability. Thus, directing chondrocyte toward a desired location and function by utilizing the mechanical cues of biomaterials is a promising approach for effective tissue regeneration. However, chondrocytes cultured on Petri dish will lose their typical phenotype which may lead to compromised results. Therefore, we fabricated polydimethylsiloxane (PDMS) materials with various stiffness… CONTINUE READING
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