Soft tissue leiomyosarcomas and malignant gastrointestinal stromal tumors: differences in clinical outcome and expression of multidrug resistance proteins.

@article{Plaat2000SoftTL,
  title={Soft tissue leiomyosarcomas and malignant gastrointestinal stromal tumors: differences in clinical outcome and expression of multidrug resistance proteins.},
  author={Boudewijn E.Ch. Plaat and Harry Hollema and Willemina M. Molenaar and G H Torn Broers and Justin Pijpe and Mirjam F. Mastik and Harald Joan Hoekstra and Else van den Berg and Rik J. Scheper and Winette T. A. van der Graaf},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2000},
  volume={18 18},
  pages={3211-20}
}
PURPOSE Several studies have reported clinical behavior and chemotherapy resistance in leiomyosarcomas, but these studies did not differentiate between soft tissue leiomyosarcomas (LMS) and malignant gastrointestinal stromal tumors (GIST). Multidrug resistance (MDR) has been associated with the expression of P-glycoprotein (P-gp), multidrug resistance protein (MRP(1)), and lung resistance protein (LRP). The aim of the present study was to compare LMS and GIST with respect to clinical outcome… CONTINUE READING

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