Soft tissue: Hibernomas
- AF Mavrogenis, L. Coll-Mesa
- Atlas Genet Cytogenet Oncol Haematol
Note Brown adipose tissue is rich in glycogen, cholesterol and phospholipids. In contrast to white adipose tissue, which stores energy, brown fat is involved in nonshivering thermogenesis. This ability is dependent on the expression of uncoupling protein 1 (UCP1), a mitochondrial proton transporter that uncouples electron transport from ATP production. In humans, brown adipose tissue typically accumulates within the neck, axillae, back, subpleural regions, mediastinum, abdomen and thigh, and is more profuse in the fetus and neonate, in whom it constitutes approximately 5% of body weight. Beginning at about 8 weeks after birth brown adipose tissue gradually decreases. In adult life, it progressively disappears and is confined to the more central parts of the body, which leads to a vest-like arrangement with the greatest yields of brown fat in perirenal, posterior cervical and axillary lymph nodes, and intercostals areas.