Sodium valproate induces cell senescence in human hepatocarcinoma cells.

@article{An2013SodiumVI,
  title={Sodium valproate induces cell senescence in human hepatocarcinoma cells.},
  author={Hong-mei An and Yong-Fei Xue and Yan-Li Shen and Qin Du and Bing Hu},
  journal={Molecules},
  year={2013},
  volume={18 12},
  pages={14935-47}
}
Hepatocarcinogenesis is associated with epigenetic changes, including histone deacetylases (HDACs). Epigenetic modulation by HDAC inhibition is a potentially valuable approach for hepatocellular carcinoma treatment. In present study, we evaluated the anticancer effects of sodium valproate (SVP), a known HDAC inhibitor, in human hepatocarcinoma cells. The results showed SVP inhibited the proliferation of Bel-7402 cells in a dose-dependent manner. Low dose SVP treatment caused a large and flat… CONTINUE READING