Sodium valproate-induced cardiovascular abnormalities in the Jcl:ICR mouse fetus: peak sensitivity of gestational day and dose-dependent effect.

@article{Sonoda1993SodiumVC,
  title={Sodium valproate-induced cardiovascular abnormalities in the Jcl:ICR mouse fetus: peak sensitivity of gestational day and dose-dependent effect.},
  author={Tohru Sonoda and Shozo Ohdo and Ken-ichi Ohba and Takahiro Okishima and Kunio Hayakawa},
  journal={Teratology},
  year={1993},
  volume={48 2},
  pages={127-32}
}
Sodium valproate was administered to Jcl:ICR mice in order to determine its effect on cardiovascular development. A single dose of 600 mg/kg of sodium valproate was injected intraperitoneally on gestational days 6, 7, 8, or 9. In same animals, a single dose of 300, 400, 500, or 700 mg/kg was injected on gestational day 7. On day 18 of gestation, dams were… CONTINUE READING