Sodium valproate, a histone deacetylase inhibitor, but not captopril, prevents right ventricular hypertrophy in rats.

@article{Cho2010SodiumVA,
  title={Sodium valproate, a histone deacetylase inhibitor, but not captopril, prevents right ventricular hypertrophy in rats.},
  author={Young Kuk Cho and Gwang Hyeon Eom and Hae Jin Kee and Hyung-Seok Kim and W. Choi and Kwang-Il Nam and Jae Sook Ma and Hyun Kook},
  journal={Circulation journal : official journal of the Japanese Circulation Society},
  year={2010},
  volume={74 4},
  pages={760-70}
}
BACKGROUND Although right ventricular hypertrophy (RVH) is an adaptive process to stresses such as outflow tract obstruction, uncorrected persistent RVH often results in failure of the right ventricle or even the left ventricle. Histone deacetylase (HDAC) inhibitors can effectively prevent or block left ventricular hypertrophy, so the present study compared the effects of sodium valproate, an HDAC inhibitor, with those of captopril, an angiotensin-converting enzyme inhibitor, on RVH. METHODS… CONTINUE READING

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