Sodium taurocholate cotransporting polypeptide inhibition efficiently blocks hepatitis B virus spread in mice with a humanized liver

@inproceedings{Nakabori2016SodiumTC,
  title={Sodium taurocholate cotransporting polypeptide inhibition efficiently blocks hepatitis B virus spread in mice with a humanized liver},
  author={Tasuku Nakabori and Hayato Hikita and Kazuhiro Murai and Yasutoshi Nozaki and Yugo Kai and Hirohisa Yano and Yoshinobu Saito and Satoshi Tanaka and Hiromi Wada and Hidetoshi Eguchi and Takeshi Takahashi and Hiroshi Suemizu and Ryotaro Sakamori and Naoki Hiramatsu and Tomohide Tatsumi and Tetsuo Takehara},
  booktitle={Scientific reports},
  year={2016}
}
Sodium taurocholate cotransporting polypeptide (NTCP) is a recently discovered hepatitis B virus (HBV) receptor. In the present study, we used TK-NOG mice with a humanized liver to examine the impact of endogenous NTCP expression on HBV infection. Upon inoculation with HBV, these mice exhibited clear viremia in 2 weeks, and serum HBV DNA levels gradually increased. The frequency of HBsAg-positive hepatocytes in the liver was 5.1 ± 0.6% at 2 weeks and increased with increasing HBV DNA levels… CONTINUE READING
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