Sodium tanshinone IIA sulfonate derived from Danshen (Salvia miltiorrhiza) attenuates hypertrophy induced by angiotensin II in cultured neonatal rat cardiac cells.

@article{Takahashi2002SodiumTI,
  title={Sodium tanshinone IIA sulfonate derived from Danshen (Salvia miltiorrhiza) attenuates hypertrophy induced by angiotensin II in cultured neonatal rat cardiac cells.},
  author={Kyoko C Takahashi and Xinshou Ouyang and Katsuko Komatsu and Norio Nakamura and Masao Hattori and A. Ramesha Baba and Junichi Azuma},
  journal={Biochemical pharmacology},
  year={2002},
  volume={64 4},
  pages={745-9}
}
Sodium tanshinone IIA sulfonate (STS), a derivative of tanshinone IIA, is isolated from the root of Salvia miltiorrhiza known as "Danshen." Although injection of S. miltiorrhiza extract and STS is used widely and successfully in clinics in China for treating cardiovascular diseases, the exact mechanism for its therapeutic basis is poorly understood. The present study was undertaken to characterize the effect of STS on angiotensin II-induced hypertrophy on cultured myocytes and cardiac… CONTINUE READING
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