Sodium tanshinone IIA sulfonate depresses angiotensin II-induced cardiomyocyte hypertrophy through MEK/ERK pathway

@article{Yang2007SodiumTI,
  title={Sodium tanshinone IIA sulfonate depresses angiotensin II-induced cardiomyocyte hypertrophy through MEK/ERK pathway},
  author={Le Yang and Xiaojing Zou and Qiansheng Liang and Hao Chen and Jun Feng and Li Yan and Zhaohua Wang and Daixing Zhou and Shusheng Li and Shanglong Yao and Zhi Hao Zheng},
  journal={Experimental & Molecular Medicine},
  year={2007},
  volume={39},
  pages={65-73}
}
Cardiomyocyte hypertrophy is a major cause of morbidity and mortality worldwide. The aim of this study is to determine the effects of sodium tanshinone IIA sulfonate (STS) on cardiomyocyte hypertrophy induced by angiotensin II (Ang II) in vivo and in vitro. In long-term treatment, adult Wistar rats were infused with Ang II for three weeks via osmotic mini-pumps and some of them were given intragastrically of STS. Left ventricle was isolated; the ratio of left ventricular weight to body weight… CONTINUE READING

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