Sodium sulfide prevents water diffusion abnormality in the brain and improves long term outcome after cardiac arrest in mice.

@article{Kida2012SodiumSP,
  title={Sodium sulfide prevents water diffusion abnormality in the brain and improves long term outcome after cardiac arrest in mice.},
  author={Kotaro Kida and Shizuka Minamishima and Huifang Wang and Jiaqian Ren and Kazim Yiğitkanli and Ala Nozari and Joseph B. Mandeville and Philip K. Liu and Christina H. Liu and Fumito Ichinose},
  journal={Resuscitation},
  year={2012},
  volume={83 10},
  pages={1292-7}
}
AIM OF THE STUDY Sudden cardiac arrest (CA) is one of the leading causes of death worldwide. Previously we demonstrated that administration of sodium sulfide (Na(2)S), a hydrogen sulfide (H(2)S) donor, markedly improved the neurological outcome and survival rate at 24 h after CA and cardiopulmonary resuscitation (CPR) in mice. In this study, we sought to elucidate the mechanism responsible for the neuroprotective effects of Na(2)S and its impact on the long-term survival after CA/CPR in mice… CONTINUE READING
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