Sodium stibogluconate resistance in Leishmania donovani correlates with greater tolerance to macrophage antileishmanial responses and trivalent antimony therapy.

@article{Carter2005SodiumSR,
  title={Sodium stibogluconate resistance in Leishmania donovani correlates with greater tolerance to macrophage antileishmanial responses and trivalent antimony therapy.},
  author={Katharine C. Carter and Sylvia Hutchison and A. Boitelle and Henry W. Murray and Shyam Sundar and Alexander Balfour Mullen},
  journal={Parasitology},
  year={2005},
  volume={131 Pt 6},
  pages={747-57}
}
Co-treatment of mice infected with different strains of Leishmania donovani with a non-ionic surfactant vesicle formulation of buthionine sulfoximine (BSO-NIV), and sodium stibogluconate (SSG), did not alter indicators of Th1 or Th2 responses but did result in a significant strain-independent up-regulation of IL6 and nitrite levels by stimulated splenocytes from treated mice compared to controls. The efficacy of BSO-NIV/SSG treatment was dependent on the host being able to mount a respiratory… CONTINUE READING

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