Sodium selenosulfate at an innocuous dose markedly prevents cisplatin-induced gastrointestinal toxicity.

@article{Li2012SodiumSA,
  title={Sodium selenosulfate at an innocuous dose markedly prevents cisplatin-induced gastrointestinal toxicity.},
  author={Jun Li and Kang Sun and Lijuan Ni and Xufang Wang and Dongxu Wang and Jinsong Zhang},
  journal={Toxicology and applied pharmacology},
  year={2012},
  volume={258 3},
  pages={
          376-83
        }
}
Our previous studies in mice revealed that two weeks short-term toxicity of sodium selenosulfate was significantly lower than that of sodium selenite, but selenium repletion efficacy of both compounds was equivalent. In addition, we showed that sodium selenosulfate reduced nephrotoxicity of cisplatin (CDDP) without compromising its anticancer activity, thus leading to a dramatic increase of cancer cure rate from 25% to 75%. Hydration has been used in clinical practice to reduce CDDP-induced… CONTINUE READING
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