Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models.

@article{Eersel2010SodiumSM,
  title={Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models.},
  author={Janet van Eersel and Yazi D. Ke and Xin Liu and Fabien Delerue and Jillian J. Kril and J{\"u}rgen G{\"o}tz and Lars M Ittner},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 31},
  pages={13888-93}
}
Alzheimer's disease (AD) brains are characterized by amyloid-beta-containing plaques and hyperphosphorylated tau-containing neurofibrillary tangles (NFTs); however, in frontotemporal dementia, the tau pathology manifests in the absence of overt amyloid-beta plaques. Therapeutic strategies so far have primarily been targeting amyloid-beta, although those targeting tau are only slowly beginning to emerge. Here, we identify sodium selenate as a compound that reduces tau phosphorylation both in… CONTINUE READING

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A role for FKBP52 in Tau protein function

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