Sodium salicylate activates caspases and induces apoptosis of myeloid leukemia cell lines.

@article{Klampfer1999SodiumSA,
  title={Sodium salicylate activates caspases and induces apoptosis of myeloid leukemia cell lines.},
  author={Lidija Klampfer and Jorg Cammenga and H G Wisniewski and Stephen Nimer},
  journal={Blood},
  year={1999},
  volume={93 7},
  pages={2386-94}
}
Nonsteroidal antiinflammatory agents (NSAIA) have been shown to exert potent chemopreventive activity against colon, lung, and breast cancers. In this study, we show that at pharmacological concentrations (1 to 3 mmol/L) sodium salicylate (Na-Sal) can potently induce programmed cell death in several human myeloid leukemia cell lines, including TF-1, U937, CMK-1, HL-60, and Mo7e. TF-1 cells undergo rapid apoptosis on treatment with Na-Sal, as indicated by increased annexin V binding capacity… CONTINUE READING
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