Sodium pumps: ouabain, ion transport, and signaling in hypertension.

@article{Blaustein2007SodiumPO,
  title={Sodium pumps: ouabain, ion transport, and signaling in hypertension.},
  author={Mordecai P. Blaustein and John M. Hamlyn and Thomas L. Pallone},
  journal={American journal of physiology. Renal physiology},
  year={2007},
  volume={293 1},
  pages={
          F438; author reply F439
        }
}
TO THE EDITOR: A recent Editorial Focus in this journal (7) addresses the newly recognized role of the sodium pump as both an ion transport protein and a hormone receptor with its own signaling cascade. The relative importance of the cardiotonic steroids (CTS) as endogenous signaling hormones versus their ability to inhibit the sodium pump is of great interest. Indeed, the article noted that “although all digitalislike compounds inhibit Na-K-ATPase-mediated transport, they differ considerably… 
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This chapter will outline the structure, function, and regulation of the Na/K-ATPase under normal as well as hypoxic/ischemic conditions, and outline the emerging role of ouabain and other Na/k-atPase inhibitors as endogenous hormones.
Oxidant Stress Amplification by Cardiotonic Steroids as Therapeutic Target in Chronic Kidney Disease and Heart Failure
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It is shown that CS induces the formation of dark structures adjacent to the nucleus in human NT2 and ACHN cells, which are clusters of glycogen and a distorted microtubule network that may be part of a new type of cellular stress response.
Digibind Reverses Inhibition of Cellular Rb+ Uptake Caused by Endogenous Sodium Pump Inhibitors Present in Serum and Placenta of Women with Preeclampsia
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These studies evidence EDLF in PE serum and Additionally, PE placentas have high EDLFs and may represent a source.
Ca2+ influx mechanisms in caveolae vesicles of pulmonary smooth muscle plasma membrane under inhibition of alpha2beta1 isozyme of Na+/K+-ATPase by ouabain.
TLDR
Inhibition of alpha(2) isoform of Na(+)/K(+)-ATPase by ouabain plays a crucial role in modulating the Ca(2+) influx regulatory components in the caveolae microdomain for marked increase in (Ca(2+))(i) in the smooth muscle, which could be important for the manifestation of pulmonary hypertension.
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Reply to Blaustein et al.
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The Editorial Focus “did not cite key articles that support the conclusion that CTS (cardiotonic steroids) hypertension is secondary to inhibition of sodium pumps,” according to the Blaustein et al.

References

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TLDR
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