Sodium pump alpha2 subunits control myogenic tone and blood pressure in mice.

@article{Zhang2005SodiumPA,
  title={Sodium pump alpha2 subunits control myogenic tone and blood pressure in mice.},
  author={Jin Zhang and Moo Yeol Lee and Maurizio Cavalli and Ling Chen and Roberto Berra-Romani and C. William Balke and Giuseppe Bianchi and Patrizia Ferrari and John M. Hamlyn and Takahiro Iwamoto and Jerry B. Lingrel and Donald R. Matteson and Withrow Gil Wier and Mordecai P. Blaustein},
  journal={The Journal of physiology},
  year={2005},
  volume={569 Pt 1},
  pages={243-56}
}
A key question in hypertension is: How is long-term blood pressure controlled? A clue is that chronic salt retention elevates an endogenous ouabain-like compound (EOLC) and induces salt-dependent hypertension mediated by Na(+)/Ca(2)(+) exchange (NCX). The precise mechanism, however, is unresolved. Here we study blood pressure and isolated small arteries of mice with reduced expression of Na(+) pump alpha1 (alpha1(+/-)) or alpha2 (alpha2(+/-)) catalytic subunits. Both low-dose ouabain (1-100 nm… CONTINUE READING

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