Sodium-potassium-chloride cotransport.
@article{Russell2000SodiumpotassiumchlorideC, title={Sodium-potassium-chloride cotransport.}, author={John M. Russell}, journal={Physiological reviews}, year={2000}, volume={80 1}, pages={ 211-76 } }
Obligatory, coupled cotransport of Na(+), K(+), and Cl(-) by cell membranes has been reported in nearly every animal cell type. This review examines the current status of our knowledge about this ion transport mechanism. Two isoforms of the Na(+)-K(+)-Cl(-) cotransporter (NKCC) protein (approximately 120-130 kDa, unglycosylated) are currently known. One isoform (NKCC2) has at least three alternatively spliced variants and is found exclusively in the kidney. The other (NKCC1) is found in nearly…
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