Sodium-potassium-chloride cotransport.

@article{Russell2000SodiumpotassiumchlorideC,
  title={Sodium-potassium-chloride cotransport.},
  author={JOHN M. Russell},
  journal={Physiological reviews},
  year={2000},
  volume={80 1},
  pages={
          211-76
        }
}
  • J. Russell
  • Published 2000
  • Biology
  • Physiological reviews
Obligatory, coupled cotransport of Na(+), K(+), and Cl(-) by cell membranes has been reported in nearly every animal cell type. This review examines the current status of our knowledge about this ion transport mechanism. Two isoforms of the Na(+)-K(+)-Cl(-) cotransporter (NKCC) protein (approximately 120-130 kDa, unglycosylated) are currently known. One isoform (NKCC2) has at least three alternatively spliced variants and is found exclusively in the kidney. The other (NKCC1) is found in nearly… 
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The results demonstrate for the first time that an intracellular loop in NKCC contributes to the transport process perhaps by forming a flexible structure that positions itself between membrane spanning domains.
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