Sodium permeability and sensitivity induced by mutations in the selectivity filter of the KcsA channel towards Kir channels.

Abstract

The bacterial potassium (K(+)) channel KcsA provides an attractive model system to study ion permeation behavior in a selective K(+)-channel. We changed residue at the N-terminal end of the selectivity filter of KcsA (T74V) to its counterpart in inwardly rectifying K(+)-channels (Kir). The tetramer was found to be stable as unmodified KcsA. Under… (More)
DOI: 10.1016/j.biochi.2009.11.007

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