Sodium oxybate and sleep apnea: a clinical case.


Sodium oxybate (GHB, Xyrem, Jazz Pharmaceuticals) is used to treat cataplexy in patients with narcolepsy. We report the case of a middle aged, normo-ponderal narcoleptic woman without risk factors who developed reversible sleep apnea and objective sleepiness when treated by sodium oxybate, with an apnea-hypopnea index (AHI) of 19.7 on sodium oxybate and AHI 4.8 without treatment. Despite a subjective improvement in vigilance, mean sleep latency on MWT decreased from 21 minutes to 8 minutes on sodium oxybate.

DOI: 10.5664/jcsm.1480

Cite this paper

@article{Hartley2011SodiumOA, title={Sodium oxybate and sleep apnea: a clinical case.}, author={S Hartley and Maria-Antonia Quera-Salva and Mourad Machou}, journal={Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine}, year={2011}, volume={7 6}, pages={667-8} }