Sodium nitrite downregulates vascular NADPH oxidase and exerts antihypertensive effects in hypertension.

@article{Montenegro2011SodiumND,
  title={Sodium nitrite downregulates vascular NADPH oxidase and exerts antihypertensive effects in hypertension.},
  author={M F Montenegro and Jefferson Henrich Amaral and Lucas C{\'e}zar Pinheiro and Eliana K Sakamoto and Graziele Cristina Ferreira and Rosana In{\'a}cio Dos Reis and Diogo M. O. Marçal and Romaiana Picada Pereira and Jos{\'e} Eduardo Tanus-Santos},
  journal={Free radical biology & medicine},
  year={2011},
  volume={51 1},
  pages={144-52}
}
Dietary nitrite and nitrate are important sources of nitric oxide (NO). However, the use of nitrite as an antihypertensive drug may be limited by increased oxidative stress associated with hypertension. We evaluated the antihypertensive effects of sodium nitrite given in drinking water for 4 weeks in two-kidney one-clip (2K1C) hypertensive rats and the effects induced by nitrite on NO bioavailability and oxidative stress. We found that, even under the increased oxidative stress conditions… CONTINUE READING
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