Sodium lactate increases LPS-stimulated MMP and cytokine expression in U937 histiocytes by enhancing AP-1 and NF-kappaB transcriptional activities.

@article{Nareika2005SodiumLI,
  title={Sodium lactate increases LPS-stimulated MMP and cytokine expression in U937 histiocytes by enhancing AP-1 and NF-kappaB transcriptional activities.},
  author={Alena Nareika and Lin He and B Andrew Game and Elizabeth H. Slate and John J. Sanders and Steven D. London and Maria F. Lopes-Virella and Yan Huang},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2005},
  volume={289 4},
  pages={E534-42}
}
The plasma lactate concentration in patients with obesity and type 2 diabetes is often higher than that in nondiabetic individuals. Although it is known that increased lactate concentration is an independent risk factor for developing type 2 diabetes, the underlying mechanisms are not well understood. Because inflammation plays an important role in the development of type 2 diabetes, we postulated that increased lactate level might contribute to the pathogenesis of type 2 diabetes by enhancing… CONTINUE READING

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