Sodium ions, calcium ions, blood pressure regulation, and hypertension: a reassessment and a hypothesis.

  title={Sodium ions, calcium ions, blood pressure regulation, and hypertension: a reassessment and a hypothesis.},
  author={Mordecai P. Blaustein},
  journal={The American journal of physiology},
  volume={232 5},
  • M. Blaustein
  • Published 1 May 1977
  • Biology
  • The American journal of physiology
An attempt is made to elucidate the cellular mechanisms which may account for the well-documented correlation between sodium metabolism and peripheral vascular resistance. As a starting point, the evidence that the Na electrochemical gradient across the vascular smooth muscle cell plasma membrane (sarcolemma) plays an important role in cell calcium regulation is reviewed. Because there is significant resting tension ("tone") in most resistance vessels, the ionized Ca2+ level ([Ca2+]1) in the… 

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