Sodium ion cycle in bacterial pathogens: evidence from cross-genome comparisons.

@article{Hse2001SodiumIC,
  title={Sodium ion cycle in bacterial pathogens: evidence from cross-genome comparisons.},
  author={Claudia C. H{\"a}se and Natalie D Fedorova and Michael Y. Galperin and P A Dibrov},
  journal={Microbiology and molecular biology reviews : MMBR},
  year={2001},
  volume={65 3},
  pages={353-70, table of contents}
}
Analysis of the bacterial genome sequences shows that many human and animal pathogens encode primary membrane Na+ pumps, Na+-transporting dicarboxylate decarboxylases or Na+ translocating NADH:ubiquinone oxidoreductase, and a number of Na+ -dependent permeases. This indicates that these bacteria can utilize Na+ as a coupling ion instead of or in addition to the H+ cycle. This capability to use a Na+ cycle might be an important virulence factor for such pathogens as Vibrio cholerae, Neisseria… CONTINUE READING