Sodium inversion recovery MRI of the knee joint in vivo at 7T.

@article{Madelin2010SodiumIR,
  title={Sodium inversion recovery MRI of the knee joint in vivo at 7T.},
  author={Guillaume Madelin and Jae-Seung Lee and Sara K. Inati and Alexej Jerschow and Ravinder R. Regatte},
  journal={Journal of magnetic resonance},
  year={2010},
  volume={207 1},
  pages={42-52}
}
The loss of proteoglycans (PG) in the articular cartilage is an early signature of osteoarthritis (OA). The ensuing changes in the fixed charge density in the cartilage can be directly linked to sodium concentration via charge balance. Sodium ions in the knee joint appear in two pools: in the synovial fluids or joint effusion where the ions are in free motion and bound within the cartilage tissue where the Na(+) ions have a restricted motion. The ions in these two compartments have therefore… CONTINUE READING

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