Sodium-induced rise in blood pressure is suppressed by androgen receptor blockade.

@article{Caplea2001SodiuminducedRI,
  title={Sodium-induced rise in blood pressure is suppressed by androgen receptor blockade.},
  author={A. Caplea and D. Seachrist and G. Dunphy and D. Ely},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2001},
  volume={280 4},
  pages={
          H1793-801
        }
}
  • A. Caplea, D. Seachrist, +1 author D. Ely
  • Published 2001
  • Chemistry, Medicine
  • American journal of physiology. Heart and circulatory physiology
Our objective was to test the hypothesis that 1) a high Na (HNa, 3%) diet would increase blood pressure (BP) in male Wistar-Kyoto (WKY) and spontaneously hypertensive Y chromosome (SHR/y) rat strains in a territorial colony; 2) sympathetic nervous system (SNS) blockade using clonidine would lower BP on a HNa diet; and 3) prepubertal androgen receptor blockade with flutamide would lower BP on a HNa diet. A 2 x 4 factorial design used rat strains (WKY, SHR/y) and treatment [0.3% normal Na (NNa… Expand
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