Sodium-induced rise in blood pressure is suppressed by androgen receptor blockade.

  title={Sodium-induced rise in blood pressure is suppressed by androgen receptor blockade.},
  author={Ann Caplea and Darcie D Seachrist and Gail Dunphy and Daniel L. Ely},
  journal={American journal of physiology. Heart and circulatory physiology},
  volume={280 4},
  • A. CapleaD. Seachrist D. Ely
  • Published 1 April 2001
  • Biology, Medicine
  • American journal of physiology. Heart and circulatory physiology
Our objective was to test the hypothesis that 1) a high Na (HNa, 3%) diet would increase blood pressure (BP) in male Wistar-Kyoto (WKY) and spontaneously hypertensive Y chromosome (SHR/y) rat strains in a territorial colony; 2) sympathetic nervous system (SNS) blockade using clonidine would lower BP on a HNa diet; and 3) prepubertal androgen receptor blockade with flutamide would lower BP on a HNa diet. A 2 x 4 factorial design used rat strains (WKY, SHR/y) and treatment [0.3% normal Na (NNa… 

Testosterone Increases: Sodium Reabsorption, Blood Pressure, and Renal Pathology in Female Spontaneously Hypertensive Rats on a High Sodium Diet

  • Bei LiuD. Ely
  • Biology, Medicine
    Advances in pharmacological sciences
  • 2011
T accelerated the development of hypertension similar to the BP pattern observed in males; the presence of ovaries attenuated the T induced increase in BP; T increased renal sodium reabsorption, and T increased glomerulosclerosis.

Flutamide increases aldosterone levels in gonadectomized male but not female Wistar rats.

Testosterone regulates BP in male and female gonadectomized rats via the AR and flutamide by itself exerts influence over aldosterone in the absence of gonadal steroid replacement suggesting AR involvement in renal sodium handling.

Oral contraceptive-induced high blood pressure is prevented by renin-angiotensin suppression in female rats but not by sympathetic nervous system blockade.

OC-induced high blood pressure is associated with cardiac hypertrophy, enhanced pressor response to angiotensin II and preserved pressorresponse to sympathetic activation, and the study suggests that the development of the OC-induced hypertension and cardiachypertrophy is mediated by RAS, but not by SNS.

Sex-specific effects of spironolactone on blood pressure in gonadectomized male and female Wistar rats.

Investigation of the effects of a low-salt vs. a high-s salt diet on blood pressure without the influence of gonadal steroids in male and female rats found sex-specific effects of the mineralo-corticoid antagonist spironolactone were clearly indicated.

Androgen receptor independent cardiovascular action of the antiandrogen flutamide

Flutamide treatment attenuated the development of hypertension in mouse renin transgenic rats with the tfm mutation and causes subsequent activation of soluble guanylyl cyclase in an active androgen receptor independent manner, which may contribute to the observed antihypertensive actions of flutamide.

Colony social stress differentially alters blood pressure and resistance-sized mesenteric artery reactivity in SHR/y and WKY male rats

It is hypothesized that chronic social stress will increase blood pressure and SNS activity more in SHR/y males compared to WKY males, resulting in increased myogenic reactivity along with decreased vasoconstriction of small mesenteric arteries.

Effects of Testosterone on Renal Function in Salt-Loaded Rats

In salt-loaded rats, testosterone seems to activate the renin-angiotensin system, resulting in sodium retention, higher BP and renal injury.

Testosterone and Blood Pressure Regulation

Net effects of androgen action seem to be vasoconstriction, atherosclerosis and stimulation of the renin-angiotensin-aldosterone system, therefore, androgens may determine blood pressure and the prevalence of cardiovascular disease.



Sexual dimorphism of blood pressure in spontaneously hypertensive rats: effects of anti-androgen treatment.

The mechanisms resulting in the greater predisposition of male subjects towards hypertension were investigated in different strains of rats with genetic hypertension and spontaneously hypertensive rats and their respective normotensive controls, and testosterone appears not to contribute directly to the maintenance of high blood pressure in established hypertension.

Castration lowers and testosterone restores blood pressure in several rat strains on high sodium diets.

The objective of this study was to determine the effect of a high sodium diet and prepubertal castration (5-6 weeks) and androgen replacement therapy on blood pressure in male normotensive,

Sympathetic nervous system influences salt appetite in four strains of rats

Stress and high sodium effects on blood pressure and brain catecholamines in spontaneously hypertensive rats.

  • D. ElyJ. Weigand
  • Biology, Psychology
    Clinical and experimental hypertension. Part A, Theory and practice
  • 1983
The data support the concept that there are important stress and Na effects upon brain neurochemistry which influence the development of hypertension in the SHR.

SHR Y chromosome enhances the nocturnal blood pressure in socially interacting rats.

Our objective was to test the hypothesis that nocturnal mean arterial pressure (MAP), heart rate (HR), and activity would be increased in 1) colony over individually caged rats and 2) the

Testosterone effects on renal norepinephrine content and release in rats with different Y chromosomes.

Renal perfusate and renal tissue NE levels were significantly elevated by testosterone, and the Y chromosome produced a significant increase in renal NE release compared with the WKY Y chromosome.

Diurnal blood pressure variation and dietary salt in spontaneously hypertensive rats.

The results indicate that WKY rats manifest an acute sensitivity to salt ingestion but have compensatory mechanisms sufficient to prevent sustained increases in mean arterial pressure; such mechanisms are lacking in SHR.

Androgen Receptor and the Testes Influence Hypertension in a Hybrid Rat Model

The results suggest that the presence of an androgen receptor and a testis-derived factor mediate the blood pressure rise in the hybrid males, and a Y chromosome effect or sex-influenced locus may be involved.

Sex hormones change adrenoceptors in blood vessels of the spontaneously hypertensive rat.

The results indicate that sex hormones (androgens) modulate numbers of alpha 1 adrenoceptors in the cardiovascular system of the male SHR.

Blood pressure and heart rate responses to mental stress in spontaneously hypertensive (SHB) and normotensive (WKY) rats on various sodium diets.

The results suggest that SHR have a greater salt requirement than WKY, as Na restriction to one-tenth of normal led to a considerable MAP reduction in SHR despite compensatory sympathetic activation, and also to attenuated pressor responses to mental stress.