Sodium fluoride evoked histamine release from mast cells. A study of cyclic AMP levels and effects of catecholamines

  title={Sodium fluoride evoked histamine release from mast cells. A study of cyclic AMP levels and effects of catecholamines},
  author={P. Alm},
  journal={Agents and Actions},
  • P. Alm
  • Published 2005
  • Chemistry, Medicine
  • Agents and Actions
Calcium triggers the secretion of histamine from mast cells after previous exposure to sodium fluoride. The secretory process can be divided into a fluoride-activation step and a calcium-induced secretory step. It was observed that the fluoride-activation step is accompanied by an elevation of cAMP levels within the cells. The attained high levels of cAMP persist during histamine release. It was further found that catecholamines do not markedly alter the fluoride-induced histamine release. It… Expand
Role of cyclic AMP in the induction of histamine secretion from mast cells
The possible role of cyclic AMP in the induction of histamine secretion is critically considered after pharmacological activation of the cell with a number of diverse ligands induced histamine release without any accompanying changes in cyclicAMP. Expand
Some characteristics of the ATP-induced histamine release from and permeabilization of rat mast cells
Adenosine 5′-triphosphate appears to be a useful cell permeabilizing tool with which to study the biochemical processes involved in mast cell activation. Expand
Influence of protein kinase C, cAMP and phosphatase activity on histamine release produced by compound 48/80 and sodium fluoride on rat mast cells
It is concluded that calcium has a negative feedback role on the cell response and TPA notably potentiates the response to fluoride, which supports its possible modulatory role on extracellular calcium-dependent stimuli. Expand
Effects of antihistamines on isolated rat peritoneal mast cells and on model membrane systems
It is proposed that histamine H1- and H2-receptor agonists and antagonists produce their effects on mast cells by a direct action on the cell membrane, with low concentrations becoming incorporated into the bilayer in such a way as to stabilize the structure and high concentrations disrupting the membrane and leading to cell lysis. Expand
Surface histamine receptors in rat peritoneal mast cells. Separation of receptor-bearing cells via binding to a histamineprotein conjugate, Cell-ectTM
The Seragen Cell-ect Total Histamine kitTM was used to separate histamine receptor-bearing rat peritoneal mast cells from cells lacking these receptors, and suggest that the mast cell histamine receptors present are mainly of an H1-type, as judged by the capacity of a specific H2-antagonist to reduce the histamineceptor-dependent cell adhesion. Expand
Auranofin modulates mast cell histamine and polymorphonuclear leukocyte collagenase release
Results suggest that therapeutic action of auranofin may be caused, at least in part, by the inhibition of cellular release of histamine and collagenase in the course of inflammation. Expand


Histamine release by calcium from sodium fluoride-activated rat mast cells. Further evidence for a secretory process.
The results suggest that calcium-induced histamme secretion from fluoride-activated cells conforms to a secretory system which, in many respects, is governed by similar regulatory factors as for antigen and other secretagogues. Expand
Elevated cyclic AMP levels fail to inhibit extracellular calcium dependent histamine secretion from rat mast cells.
Abstract Rat mast cells preincubated with chelating agent and bathed in calcium-free medium fail to release histamine when stimulated by compound 48/80 and show elevated levels of cyclic AMP. WhenExpand
Cyclic nucleotide involvement in histamine release from mast cells--a reevaluation.
It is suggested that the lowered levels of cAMP lead to an increase in membrane permeability towards calcium and that an influx of such ions triggers the release mechanisms, but evidence has now accumulated indicating that this general concept is far too simplistic. Expand
Sodium fluoride--a stimulus for a calcium-triggered secretory process.
The secretory response induced by compound 48/80 in the absence of extracellular calcium was found to decrease after fluoride pretreatment of the cells, but the response was, however, unaffected, provided calcium was introduced to the cells simultaneously with compound48/80. Expand
Inhibition of histamine secretion from mast cells
It is shown here that a variety of anti-allergic drugs are potent inhibitors in the conditions used, suggesting that alternative explanations for their action must be sought. Expand
Role of intra- and extracellular calcium in histamine release from rat peritoneal mast cells
Evidence is provided for a number of calcium pools important in histamine secretion from the mast cell that are able to mobilize deeply buried or internal stores of calcium to initiate exocytosis and calcium bound to regulatory sites in the membrane may modulate the secretory process. Expand
Effects of indomethacin on cyclic nucleotide levels and histamine release from rat serosal mast cells.
Those changes in cyclic nucleotide levels that are suppressed by indomethacin are not part of the primary activation-secretion event of mast cells and may be secondary to the generation of oxidative products of arachidonate. Expand
Effects of norepinephrine on transmembrane calcium transport in rat mast cells.
  • P. Alm, G. Bloom
  • Biology, Medicine
  • International archives of allergy and applied immunology
  • 1981
Data indicate that the suppressive effect of norepinephrine (concentrations less than 10(-3) M) on histamine release from rat mast cells is due to an interference in transmembrane passage of calcium. Expand
Cyclic AMP, ATP, and reversed anaphylactic histamine release from rat mast cells.
Reversed anaphylactic histamine release by rabbit (Rab) anti-Rat Fab was independent of serum factors and was established as being noncytolytic in that challenged isolated mast cells still retainedExpand
Effect of norepinephrine on in vitro histamine release from rat mast cells.
  • P. Alm, G. Bloom
  • Chemistry, Medicine
  • International archives of allergy and applied immunology
  • 1979
The present results would seem to suggest that the repressive effect on histamine release, observed within a low concentration range of norepinephrine, may be due to alpha-adrenoceptor mechanisms. Expand