Sodium fluoride evoked histamine release from mast cells. A study of cyclic AMP levels and effects of catecholamines

@article{Alm2005SodiumFE,
  title={Sodium fluoride evoked histamine release from mast cells. A study of cyclic AMP levels and effects of catecholamines},
  author={P. Alm},
  journal={Agents and Actions},
  year={2005},
  volume={13},
  pages={132-137}
}
  • P. Alm
  • Published 2005
  • Chemistry, Medicine
  • Agents and Actions
Calcium triggers the secretion of histamine from mast cells after previous exposure to sodium fluoride. The secretory process can be divided into a fluoride-activation step and a calcium-induced secretory step. It was observed that the fluoride-activation step is accompanied by an elevation of cAMP levels within the cells. The attained high levels of cAMP persist during histamine release. It was further found that catecholamines do not markedly alter the fluoride-induced histamine release. It… Expand
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The results suggest that calcium-induced histamme secretion from fluoride-activated cells conforms to a secretory system which, in many respects, is governed by similar regulatory factors as for antigen and other secretagogues. Expand
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