Sodium fluoride dissolution of human calcium oxalate/phosphate stone particles.

  title={Sodium fluoride dissolution of human calcium oxalate/phosphate stone particles.},
  author={Roger K. Low and Sunita P. Ho and Marshall L. Stoller},
  journal={Journal of endourology},
  volume={9 5},
The dissolutive effects of sodium fluoride on human calcium stone particles were investigated in an in vitro model. Stone particles composed of 65% calcium oxalate and 35% calcium phosphate dissolved in a dose-dependent fashion with NaF exposure. Stone particles exposed to 60 mM NaF had a 17% reduction in particle mass after 24 hours and a 62% reduction after 7 days in comparison with experimental controls bathed in physiologic normal saline. The systemic toxicity of the dose of oral fluoride… 

The Relationship between High Fluoride Intake and Nephrolithiasis

The results suggest that the forma-tion of CaF2 crystals in urine, even considering the excretion of high amounts of fluoride ions, is very unlikely, and other factors must also exist, such as retention of Caf2 crystals and deficit of crystallization inhibitors.

Development of an in vitro Assay for the Screening of Substances Capable of Dissolving Calcium Oxalate Crystals

A simple assay that requires only inexpensive equipment available in most laboratories for the screening of substances potentially capable of dissolving CaOx crystals was developed, and a good linear correlation was found between the affinity for calcium and the activity of EDTA, sodium citrate, sodium sulfate, malic acid, succinic acid and gluconic acid.

An Approach to Breast Cancer Diagnosis via PET Imaging of Microcalcifications Using 18F-NaF

Preliminary evidence that 18F-NaF PET imaging can be used to detect breast cancer by targeting the hydroxyapatite lattice within the tumor microenvironment with high specificity and soft-tissue contrast-to-background ratio is provided.



Inhibitory effect of fluoride on renal stone formation in rats.

It is indicated that NaF can inhibit renal stone formation induced by EG by decreasing oxalate synthesis and urinary oxalATE excretion, and suggests a possible clinical therapeutic value of NaF in the prevention of oxalates kidney stones.

Role of fluoride in formation of urinary calculi: studies in rats.

It is indicated that ingestion of excess fluoride facilities calcium oxalate crystalluria and promotes the formation of bladder stones in rats, under the experimental conditions used.

Urinary fluoride excretion in responders and nonresponders after fluoride therapy in osteoporosis

Urinary fluoride excretion is a valuable predictor of BMC response during fluoride therapy for osteoporosis and a positive correlation was obtained between the changes in BMC and urinary fluoride excrete.

Effect of Stannous and Fluoride Ions on the Rate of Crystal Growth of Hydroxyapatite

Stannous and fluoride ions affected the rate of crystal growth of calcium phosphate from stable, supersaturated solutions inoculated with pure synthetic hydroxyapatite seed. Stannous ions appeared to

Incidence of urolithiasis and composition of household water in southern Finland.

The incidence of ureteral and renal stone did not vary according to natural fluoride content of drinking water, but it was lower in a city with fluoridated water than in a reference city.

The Physiological and Toxicological Characteristics of Fluoride

It is concluded that non-dietary sources of fluoride, mainly fluoride-containing dental products, are a major source of ingested fluoride.