Sodium-dependent phosphate cotransporters and phosphate-induced calcification of vascular smooth muscle cells: redundant roles for PiT-1 and PiT-2.

@article{Crouthamel2013SodiumdependentPC,
  title={Sodium-dependent phosphate cotransporters and phosphate-induced calcification of vascular smooth muscle cells: redundant roles for PiT-1 and PiT-2.},
  author={Matthew H. Crouthamel and Wei Ling Lau and Elizabeth M. Leaf and Nicholas W. Chavkin and Mary Catherine Wallingford and Danielle F Peterson and Xianwu Li and Yong-gang Liu and Michael T. Chin and Moshe Levi and Cecilia M. Giachelli},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2013},
  volume={33 11},
  pages={2625-32}
}
OBJECTIVE Elevated serum phosphate has emerged as a major risk factor for vascular calcification. The sodium-dependent phosphate cotransporter, PiT-1, was previously shown to be required for phosphate-induced osteogenic differentiation and calcification of cultured human vascular smooth muscle cells (VSMCs), but its importance in vascular calcification in vivo and the potential role of its homologue, PiT-2, have not been determined. We investigated the in vivo requirement for PiT-1 in vascular… CONTINUE READING
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Renal Data System (usrds) 2011 Annual Data Report Atlas of End-Stage Renal Disease in the United States National Institute of Diabetes and Digestive and Kidney Diseases

  • National Institutes of Health
  • 2013

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