Sodium-dependent high-affinity uptake of taurine by isolated rat brain capillaries.

@article{Tayarani1989SodiumdependentHU,
  title={Sodium-dependent high-affinity uptake of taurine by isolated rat brain capillaries.},
  author={I Tayarani and I Clo{\"e}z and J. M. Lefauconnier and J. M. Bourre},
  journal={Biochimica et biophysica acta},
  year={1989},
  volume={985 2},
  pages={168-72}
}
Transport of taurine has been demonstrated in capillary preparations from adult rat brains using [3H]taurine. Taurine transport is mediated by a saturable high-affinity system which is entirely dependent on sodium ions. The apparent maximal influx (Vmax) and half-saturation concentration (Km) corresponded to 1.06.10(-4) mumol/min per mg protein and 27.5 microM, respectively. Competition experiments in the presence of sodium ion showed that [3H]taurine uptake was strongly inhibited by 0.1 mM… CONTINUE READING