Sodium currents in medullary neurons isolated from the pre-Bötzinger complex region.

  title={Sodium currents in medullary neurons isolated from the pre-B{\"o}tzinger complex region.},
  author={Krzysztof Ptak and Greer G Zummo and George F. Alheid and Tatiana Tkatch and D. James Surmeier and Donald R. McCrimmon},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={25 21},
The pre-Bötzinger complex (preBötC) in the ventrolateral medulla contains interneurons important for respiratory rhythm generation. Voltage-dependent sodium channels mediate transient current (I(NaT)), underlying action potentials, and persistent current (I(NaP)), contributing to repetitive firing, pacemaker properties, and the amplification of synaptic inputs. Voltage-clamp studies of the biophysical properties of these sodium currents were conducted on acutely dissociated preBötC region… CONTINUE READING