Sodium-coupled and electrogenic transport of B-complex vitamin nicotinic acid by slc5a8, a member of the Na/glucose co-transporter gene family.

@article{Gopal2005SodiumcoupledAE,
  title={Sodium-coupled and electrogenic transport of B-complex vitamin nicotinic acid by slc5a8, a member of the Na/glucose co-transporter gene family.},
  author={Elangovan Gopal and You-jun Fei and Seiji Miyauchi and Lina Zhuang and Puttur D Prasad and Vadivel Ganapathy},
  journal={The Biochemical journal},
  year={2005},
  volume={388 Pt 1},
  pages={309-16}
}
SMCT (sodium-coupled monocarboxylate transporter; slc5a8) is a Na+-coupled transporter for lactate, pyruvate and short-chain fatty acids. Similar to these already known substrates of SMCT, the water-soluble B-complex vitamin nicotinic acid also exists as a monocarboxylate anion (nicotinate) under physiological conditions. Therefore we evaluated the ability of SMCT to mediate the uptake of nicotinate. In mammalian cells, the cloned mouse SMCT (slc5a8) induced the uptake of nicotinate. The SMCT… CONTINUE READING
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